Publications | Department of Chemistry


Submitted Manuscripts (UNT students / postdocs indicated with #; undergraduate students; * = corresponding author)

1. Rajendran S,# Li L,# Skellam E* (in revision)

In Preparation (UNT students / postdocs indicated with #; undergraduate students; * = corresponding author)

1. Amorim M,# Schoellhorn S,# Skellam E,* Berlinck RGS* et al.

2. Berlinck RGS and Skellam E

3. Tammam M, Pereira F, Skellam E, Ganesan A, El-Demerdash, A.

3. Li L,# Chy MNU,# Amorim M,# Goralczyk J, Skellam E*

4. Schoellhorn S,# Lim T, Sartor I, Nyugen T, Skellam E*

5. Jayasundara S,# Rajendran S,# Skellam E* et al.

Publications from Independent Career at UNT

5. Neupane S, Amorim M, Skellam E* (2024), Discovery of unguisin J, a new cyclic peptide from Aspergillus heteromorphus CBS 117.55, and phylogeny-based bioinformatic analysis of UngA NRPS domains, Beilstein Journal of Organic Chemistry, 20, 321-330

4. Skellam E* (2022), "Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes", Natural Product Reports, 39, 754-783

3. Skellam E* (2022), "Subcellular localization of fungal specialized metabolites", Fungal Biology and Biotechnology, 9, 11.

2. Skellam E (ed) Engineering Natural Product Biosynthesis (Methods and Protocols), Methods in Molecular Biology (vol 2489), 2022:

1. Skellam E* (2021), "Analysis of the secondary metabolism in Magnaporthe oryzae", In: Jacob S. (eds) Magnaporthe oryzae. Methods in Molecular Biology (vol 2356). Humana, New York, NY.

Research Prior to UNT

22. Shenouda ML, Ambilika M, Skellam E, Cox RJ (2022). "Heterologous Expression of Secondary Metabolite Genes in Trichoderma reesei for Waste Valorization". Journal of Fungi, 8, 4, 355.

21. Feng J, Hauser M, Cox RJ, Skellam E* (2021), "Engineering Aspergillus oryzae for the Heterologous Expression of a Bacterial Polyketide Synthase", Journal of Fungi, 7, 12, 1085. *Editor's Choice*

20. Kahlert L, Bernardi D, Hauser M, Ioca LP, Berlinck RGS, Skellam EJ, Cox RJ (2021), "Early Oxidative Transformations During the Biosynthesis of Terrein and Related Natural Products", Chem. Eur. J., 27, 11895-11903,

19. Kahlert L, Villanueva M, Cox RJ*, Skellam EJ* (2021), "Biosynthesis of 6-hydroxymellein requires a collaborating polyketide synthase-like enzyme", Angew. Chem. Int. Ed., 60,11423-11429.

18. Zhang H, Hantke V, Bruhnke P, Skellam E,* Cox RJ (2020), "Chemical and Genetic Studies on the Formation of Pyrrolones During the Biosynthesis of Cytochalasans", Chem. Eur. J., 27, 3106-3133.

17. Kahlert L, Cox RJ, Skellam E* (2020), "The Same but Different: Multiple Functions of the Fungal Flavin Dependent Monooxygenase SorD from Penicillium chrysogenum", Chem. Commun., 56, 10934 - 10937.

16. Wang C, Lambert C, Hauser M, Deuschmann A, Zeilinger C, Stradal T, Rottner K, Stadler M, Skellam EJ, and Cox RJ (2020), "Diversely functionalised cytochalasins via mutasynthesis and semi-synthesis", Chem. Eur. J., 26, 13578-13583, *Featured Front Page Article*.

15. Kahlert L, Bassiony E, Cox RJ and Skellam E* (2020), "Diels-Alder reactions during the biosynthesis of sorbicillinoids", Angew. Chem. Int. Ed., 59, 5816 - 5822. *Highlighted in "Hot off the Press"* (Nat. Prod. Rep., 2020, 37, 747-751)

14. Hantke V, Skellam E and Cox RJ (2020), "Evidence for Enzyme Catalysed Intramolecular [4+2] Diels-Alder Cyclization During the Biosynthesis of Pyrichalasin H", Chem. Commun., 2020, 56, 2925 - 2928. *Highlighted in "Hot off the Press"* (Nat. Prod. Rep., 2020, 37, 472-476)

13. Cox RJ and Skellam E (2020), "Non-reducing polyketide synthases in fungi: mechanisms and pathways", Comprehensive Natural Products III: Chemistry and Biology, Volume 1 (Elsevier), 266-312.

12. Skellam E* (2019), "Strategies for engineering natural product biosynthesis in fungi", Trends in Biotechnology, 37, 416-427. *Featured Front Page Article*.

11. Hantke V, Wang C, Skellam E and Cox RJ (2019), "Function of pathway specific regulators in the ACE1 and pyrichalasin H biosynthetic gene clusters", RSC Advances, 9, 35797-35802.

10. Wang C, Becker K, Pfuetze S, Kuhnert E, Stadler M, Cox RJ and Skellam E*(2019) "Investigating the Function of Cryptic Cytochalasan Cytochrome P450 Monooxygenases Using Combinatorial Biosynthesis", Org. Lett., 21, 21, 8756-8760.

9. Wang C, Hantke V, Cox RJ and Skellam E* (2019), "Targeted gene inactivations expose silent cytochalasans in Magnaporthe grisea NI980", Org. Lett., 21, 11, 4163-4167. *Highlighted in "Hot off the Press"* (Nat. Prod. Rep., 2019, 36, 1039-1043).

8. Cox RJ, Skellam E, Williams K, (2018), "Biosynthesis of Fungal Polyketides", The Mycota Vol. XV: Physiology and Genetics 2nd ed. (Springer), 385- 412.

7. Skellam E* (2017), "The biosynthesis of cytochalasans", Nat. Prod. Rep., 34, 1252-1263.

6. Song Z, Bakeer WIMM, Marshall JW, Yakasai AA, Khalid RM, Collemare J, Skellam E, Tharreau D, Lebrun MH, Lazarus CM, Bailey AM, Simpson TJ & Cox RJ (2015), "Heterologous expression of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae", Chem. Sci., 6, 4837-4845.

5. Skellam EJ, Stewart AK, Strangman W, Wright JLC (2013), "Identification of micromonolactam, a new polyene lactam from two marine Micromonospora strains using chemical and molecular methods: Clarification of the biosynthetic pathway from a glutamate starter unit", J. Antibiotics, 66, 431-441.

4. Fisch KM, Skellam E, Ivison D, Cox RJ, Bailey AM, Lazarus CM, Simpson TJ (2010), "Catalytic role of the C-terminal domains of a fungal non-reducing polyketide synthase", Chem. Commun., 46, 5331 - 5333.

3. Skellam EJ, Hurley D, Davison J, Lazarus CM, Simpson TJ, Cox RJ (2010), "Mutation of key residues in the C-methytransferase domain of a fungal highly reducing polyketide synthase", Mol. BioSys., 6, 680 - 682.

2. Bailey AM, Cox RJ, Harley K, Lazarus CM, Simpson TJ, Skellam E (2007), "Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis", Chem. Commun., 4053 - 4055.

1. Smith BM, Skellam EJ, Oxley SJ, Graham AE (2007), "Highly selective synthesis of oxabicycloalkanes by indium tribromide mediated cyclization reactions of epoxyalkanes", Org. Biomol. Chem., 5, 1979 - 1982.